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Minerva July 2002
Betel nut users put themselves at a high risk of oral cancer because the nuts induce chromosomal abnormalities. One analysis has identified that a loss in the short arm of chromosome 4 and a gain in the short arm of chromosome 9 are good predictors of prognosis. These losses are positively associated with poor outcome (Oral Oncology 2002;38:266-73).
A 37 year old
man had a renal transplant performed 22 years ago and was taking
azathioprine and prednisolone for immunosuppression. He was lost to
follow up until he presented with a large squamous cell carcinoma on
the dorsum of his right index finger. He subsequently underwent a ray
amputation of his
finger.
Skin cancer is the
most common malignancy in patients with long term immunosuppression.
The incidence increases from 10% after 10 years to 40%
after 20 years. Patient education in rigorous sun protection and
surveillance is
critical.
Jin J Bong senior house officer Department of surgery, St Jamess University Hospital, Leeds LS9 7TF
Mark Lansdown Consultant
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patient
Hospitality
workers breathe in environmental tobacco smoke whether they like it or
not. Saliva samples taken before and after a typical work shift found
significantly higher cotinine concentrations in those working in places
where smoking is permitted than in smoke-free premises. They also
reported a higher prevalence of respiratory and irritation symptoms.
The cotinine concentrations reported in this study have been linked
with substantial involuntary risks for cancer and heart disease
(Tobacco Control
2002;11:125-9).
Myths
about contraceptive coils and pelvic infection persist despite evidence
that the risk of pelvic inflammatory disease rises above the background
population rate in only the first 20 days after the coil is inserted,
thereafter dropping back to the background rate. The authors of a
review in the Journal of Family Planning and Reproductive Health
Care (2002;28:61-8) conclude that drawing together the
evidence about success rates is difficult, but the T380A device remains
the gold standard, offering the best protection against
pregnancy.
Whats
the best way to tackle neck pain? A Dutch group compared once weekly
manual therapy (specific mobilisation techniques) with twice weekly
exercise therapy and continued care by a general practitioner
(painkillers, counselling, and education). Patients favoured manual
therapy over the other two, although differences in success rates and
disability scores were not statistically significant (Annals of
Internal Medicine
2002;136:713-22).
A
case report in the Scottish Medical Journal
(2002;47:34-5) highlights the contentious issue of routine serum
biochemistry testing of patients who have had a fit (as opposed to
simply relying on a good witness account and clinical judgment). A
patient who had sustained two generalised tonic-clonic seizures
was given anti-epilepsy treatment and referred to the local
first fit clinic. While there she underwent routine biochemistry
testing and was discovered to be low in calcium. Once this was
corrected she had no further need for the epilepsy
drugs.
Were
discovering that more and more organs are influenced by the positive
effects of oestrogen. A study in Obstetrics and Gynecology
(2002;99:726-30) investigated whether hearing sensitivity in
older women is associated with serum oestradiol concentrations. A
multiple logistic regression analysis found that age and hearing loss
were positively associated, as was oestradiol concentration and hearing
loss. Minerva wonders if one day women will be given a choice between
wearing a hearing aid or taking hormone replacement
therapy.
General
practitioners are encouraged to investigate any child who presents with
a urinary tract infection. Reviewing the use of renal ultrasonography
and voiding cystourethrograms in children with their first urinary
tract infection, a study in Archives of Disease in Childhood
(2002;86:419-21) concludes that ultrasound findings are neither
sensitive nor specific for vesicoureteral reflux. The positive
predictive value of ultrasonography in determining reflux was
32%; the negative predictive value was
82%.
Now
heres a sensitive subject. An osteopath writing in the
Osteopath (2002;5:30) says that some practitioners have been
experiencing frontal headaches, sinus pain, dry mouth, and exhaustion,
duethey suspectto an irritating chemical solvent base
used to carry modern perfumes and deodorants. Asking patients not to
wear perfumes and deodorants has lost his clinic two clients to date,
but hes also concerned about liabilities for staff
health.
Minerva
was interested to read another piece of evidence that atherosclerosis
has its origins in inflammation. A 20 year case-control follow
up study of men in the Honolulu heart programme has found that C
reactive protein in serum, measured over time (starting when the men
were free of prevalent disease), rises in line with the odds of having
a myocardial infarction. The link was seen as early as five years into
the study, becoming more modest after 15 years (Journal of Clinical
Epidemiology
2002;55:445-51).
A 49 year
old woman was making steady progress after a subarachnoid haemorrhage.
She was receiving nutrition through a nasogastric tube. On the morning
ward round the nurses mentioned that she had vomited earlier, and there
was evidence of fresh vomit on her sheets. When she was cleaned, a
superficial burn was noted where the vomit had come into contact with
her skin. She was given a proton pump inhibitor and the burn was
treated successfully. Patients being fed via a nasogastric tube should
take a gastric protecting
agent.
Snehal Lapsia senior house officer
Paul Maguire senior house officer Department of Neurosurgery, Hope Hospital, Salford M6 8HD
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for this page should include signed consent to publication from the
patient
To
keep bone marrow cells alive and kicking (and still able to turn
themselves into a variety of different tissue types), scientists have
used prolonged culturing with the human enzyme telomerase reverse
transcriptase, which has the effect of extending the DNA sequences at
the end of the chromosomes. As a result, the cells last longer, over
more population doublings, and express proteins on their surfaces that
indicate they are capable of turning into bone, collagen, and fat cells
(Nature Biotechnology
2002;20:587-91).
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