Review: Long term effectiveness of non-drug treatments for sleep problems in young children is more evident
Ramchandani P, Wiggs L, Webb V, et al. A systematic review of treatments for settling problems and night waking in young children. BMJ 2000 Jan 22;320:209-13
QUESTION: In healthy young children, are drug and non-drug treatments effective for settling problems and night waking?
Data sources
Studies were identified by searching Medline (1966 to
September 1998), EMBASE/Excerpta Medica (1980 to
June 1998), PsycLIT (1974 to September 1998), Biological Abstracts (1985 to June 1998), CINAHL (1982 to
September 1998), SIGLE (1980 to June 1998), and the
Cochrane database (issue 2, 1998); scanning the bibliographies of identified articles and those in reviews and
books; handsearching the Journal of Child Psychology and Psychiatry; and contacting authors and manufacturers of trimeprazine.
Study selection
Studies were included if they were randomised
controlled trials (describing drug or non.drug interventions) in young children (<5 y of age) with an established
sleep or night waking problem that had an outcome
measure of number of night wakings, time to settle, or
number of nights in which these problems occurred.
Data extraction
Data were extracted on the study design, number and
age range of the participants, referral source, sleep prob.
lem, intervention and control procedures, outcome
scores and measures, and assessment times.
Main results
Nine studies met the selection criteria: four drug trials,
four on behavioural treatments, and one on a general
non-directive educational approach. A meta-analysis was
not done because of study heterogeneity. Two drug trials
compared trimeprazine (maximum dose 90 mg) with
placebo. Both showed a statistically significant positive
effect of trimeprazine in the short term. Some children
treated with trimeprazine, however, continued to wake at
night, and up to one third did not improve with
trimeprazine. Long term results were less favourable.
One trial compared niaprazine with chlordesmethyl
diazepam and found the drugs to be similarly effective.
The fourth drug trial compared trimeprazine as an
adjunct to an extinction programme with placebo and
found no difference between the groups at end of treat.
ment and at four weeks of follow up.
The non-drug interventions investigated were positive
routines, graduated extinction, scheduled wakings,
extinction or systematic ignoring, modified extinction,
an educational booklet, and a sleep programme. In both
the short and long term, scheduled wakings and extinction were more effective in reducing night waking than
was control treatment (a sleep diary), and positive
routines and graduated extinction were more effective in
reducing settling problems than was a waiting list. A
non.directive educational booklet showed no benefit
over a control procedure. The benefits of a modified extinction procedure and of a booklet giving specific
advice were unclear because no untreated control group
comparisons were done.
Conclusion
Drug and some non-drug treatments are effective in the
short term for reducing settling problems and night
waking in young children, but long term beneficial
effects are more evident with non-drug treatments.
COMMENTARY
Treatment for sleep problems in young children varies considerably by geographic
area. For example, in a study by Kopferschmitt et al,1 it was reported that some 12%
of the 11 595 children enrolled in kindergarten in the Bas Rhin province in France
had been given psychotropic medication for "sleep problems" for more than six
months and up to five years. In contrast, medication is rarely if ever given in the US
for sleep problems, but US practitioners show great interest in the effectiveness of
various behavioural approaches for sleep difficulties; these approaches have been
well documented in a recent review article.2
The review by Ramchandani et al teaches us four lessons. Firstly, drugs can have
a short term effect on sleep behaviour, but little evidence exists to suggest they have
a long term effect. One reason for this finding is that sleep problems are often a
reflection of a specific parental management style, 3 which governs a child's day and
night behaviour. This type of problem will not be modified by a sleeping pill. Secondly, many parents will not allow their young children to receive psychotropic
drugs; hence, studies of drug use for childhood sleep problems may use selective
and potentially unrepresentative populations. Thirdly, falling asleep and the
number of night wakings are influenced by the neurobehavioural development of
the infant, especially during the first six months. Thus, 75% of children six months
of age do not disturb their parents during the night, whereas virtually all do so
earlier. Fourthly, night waking is considered normal in infants. The concern over
night waking occurs when children "call out" on waking rather than soothing themselves back to sleep. 3 It is this ability that treatment needs to develop, a modification
of behaviour that cannot be accomplished in the long term with medication.
Klaus Minde, The Montreal Children's Hospital Montreal, Quebec, Canada
Email: email
studentBMJ 2000;08:435-476 December ISSN 0966-6494
- Kopferschmitt J, Meyer P, Jaege A, et al. Sleep disorders and use of psychotropic drugs in 6-year-old children. Rev Epidemiol Sante Publique 1992;40:467-71.
- Mindell JA. Empirically supported treatments in pediatric psychology: bedtime refusal and night wakings in young children. J Pediatr Psychol 1999;24:465-81.
- Minde K, Popiel K, Leos N, et al. The evaluation and treatment of sleep disturbances in young children. J Child Psychol Psychiatry 1993;34:521-33.
